Viral entry begins after the virus has attached to the host cell through nonspecific glycoproteins tethers Marsh and Helenius, The specific internalization pathway chosen by a virus depends on the characteristics of the virus, and the host cell type.
penetration Receptor virus direct mediated
Examples of this are the Togaviridae and the Coronaviridae. In this pathway, viruses bind to receptors at coated pits. To establish infection and replicate, viruses need to gain access to the intracellular environment. Major histocompatibility complex class I molecules mediate association of SV40 with caveolae.
Virus Infections and Hosts
Binding of hepatitis C virus to CD Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Clathrin- and caveolin-1—independent endocytosis: Entry of simian virus 40 into cells devoid of caveolae. Cholesterol levels in HeLa cells were determined using the Amplex Red Cholesterol Assay Kit Molecular Probes and was performed according to the manufacturer's protocol.